Update For the Prolia® Postmarketing Active Safety

Surveillance Program

Dear Health Care Professional,

Thank you for your participation in the Prolia Active Safety Surveillance Program (PASP). The PASP is no longer open for registration or processing adverse events reporting, as the solicitation of adverse events is now being conducted through an electronic medical record system. We appreciate your time and engagement in this safety program.

If you wish to report Adverse Events with Prolia®, please contact Amgen Medical Information at:

Phone: 1-800-772-6436

Email: medinfo@amgen.com

Or you may report adverse events with Prolia by contacting FDA MedWatch.

If you would like additional important safety information on Prolia, please:

Contact Amgen Medical Information at: 1-800-772-6436 or

Visit the Prolia® or Risk Evaluation and Mitigation Strategy websites.

If you have any questions or require additional information regarding the use of Prolia, please contact Amgen at 1-800-772-6436.

Thank you.